Dual Prenylation Is Required for Rab Protein Localization and Function
نویسندگان
چکیده
منابع مشابه
Dual prenylation is required for Rab protein localization and function.
The majority of Rab proteins are posttranslationally modified with two geranylgeranyl lipid moieties that enable their stable association with membranes. In this study, we present evidence to demonstrate that there is a specific lipid requirement for Rab protein localization and function. Substitution of different prenyl anchors on Rab GTPases does not lead to correct function. In the case of Y...
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Rab escort proteins (REP) 1 and 2 are closely related mammalian proteins required for prenylation of newly synthesized Rab GTPases by the cytosolic heterodimeric Rab geranylgeranyl transferase II complex (RabGG transferase). REP1 in mammalian cells is the product of the choroideremia gene (CHM). CHM/REP1 deficiency in inherited disease leads to degeneration of retinal pigmented epithelium and l...
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Introduction Covalent attachment of isoprenoid lipids is now recognized as an important modification of many proteins involved in cellular signalling [ 1,2]. This type of modification, termed prenylation, involves attachment of either the 15-carbon farnesyl or 20carbon geranylgeranyl isoprenoid to C-terminal cysteine residues of proteins. Known prenylated proteins include a number of GTP-bindin...
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Few molecular events important to platelet biogenesis have been identified. Mice homozygous for the spontaneous, recessive mutation gunmetal (gm) have prolonged bleeding, thrombocytopenia, and reduced platelet alpha- and delta-granule contents. Here we show by positional cloning that gm results from a G-->A substitution mutation in a splice acceptor site within the alpha-subunit of Rab geranylg...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2003
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e02-11-0707